Fatenicon™ Experiments

The gastrointestinal protector for antibiotic replacement, diarrhea prevention, and African Swine Fever prevention.
IntroductionExperiments

Safe and Effective

  • Hebei Jingdian Group Experimental Farm 2017.11.25 – 2017.12.10
    We selected two litters of 30-day-old weaned piglets and divided them into two groups. Each group contained five piglets from the same sow.
    * Fatenicon™ group does not use antibiotics in feed.
  • Jiangxi Ganzhou 2017.10.6 – 2017.10.23
    We selected 100 piglets of 5-week-old and divided them into two groups, three repetitions in each group. In each group, two repetitions contained 20 piglets, while the other one contained 10 piglets. Free feeding.
  • Jiangxi Experimental Farm 2019.1.17 – 2019.1.27
    We selected 60 Duroc-Landrace-Yorkshire piglets from four columns. These piglets were randomly divided into 2 groups, each group of 2 repetitions, each repetition of 15 heads.

Fatenicon™ replaces Zinc Oxide

The single-use or reasonable compatibility of Fatenicon™ can effectively reduce the use of zinc oxide, eliminate the side effects of zinc oxide, and maintain the excellent anti-diarrhea effect. Through in vitro biomimetic safety evaluation, we obtained a qualitative description of the compatibility of Fatenicon™ with traditional zinc oxide products with NPI Chemical Laboratory.

The zinc oxide used in the test was feed grade, ZnO content ≥95%, Zn content ≥80% (Pb≤0.002%, Cd≤0.0008%, As≤0.05%), and 98% passed the 150μm test sieve.

Bacteria Attack Simulation
for Fatenicon™ and Zinc Oxide in Piglet Feed

UNIVET Beijing North Laboratory 2018.1.29

Materials and Methods
We inoculated the chyme through different groups to simulate bacterial attacks and compare the damage degree of bacteria on the Fatenicon™ and zinc oxide chyme.
The test used Escherichia coli and Staphylococcus aureus from Shanghai Ruichu Co., Ltd. Zinc oxide is of analytical grade (ZnO ≥ 99%).

Test Results

Result analysis
This experiment examined the extent of damage to Fatenicon™ and zinc oxide by bacterial challenges in vitro. Among them, the chyme of S.aureus attack is thicker that of E.coli attack. As the concentration of bacteria increased, the surface layer of the zinc oxide group showed hardening. This phenomenon causes zinc oxide to detach from the surface of the intestinal mucosa, resulting in physical damage. The experiment shows that when harmful bacteria reach a specific concentration, the mucous tissue of the intestinal mucosa can be destroyed, and the zinc oxide loses the intestinal protection function.

The Fatenicon™ group showed good chyme complexing ability under the attack of bacteria with different amounts and concentrations. However, with the decrease in the quantity, although the Fatenicon™ group did not show surface hardening, the safety was reduced. Antibacterial substances can only be destroyed when they reach a specific concentration in the mucus of the digestive tract, not in vitro. This test supports Fatenicon™ to replace antibiotics in animals.

Antidiarrheal Test

  • Zhaojiawa Village, Lulong County, Hebei 2018.12.10

    This litter of piglets was raised five days after birth. All the piglets had diarrhea on day 40. The feeder mixed 0.3% of Fatenicon™ in the feed. No diarrhea was observed by naked eyes after three days.

  • Moheishi Village, Lulong County, Hebei 2018.11.28
    All the piglets in the litter had diarrhea at the weight of 16kg. The feeder mixed 0.2% of Fatenicon™ in the feed. No diarrhea was observed by naked eyes after three days.